Feed for ruminants

专利摘要:
1. A new product for feeding ruminants, which is stable in a medium in which the pH is equal to or above 5.5 and which permits the release of an active principle in a medium in which the pH is below or equal to 3.5, characterized in that it consists of an active substance or of a composition containing the active substance which contains inclusions of, or which is completely or partially covered by, a composition containing a substance which is sensitive to pH variations whose extend and rate of swelling are greater in an acidic medium than in a neutral medium, said active substance or composition containing active substance being coated with a layer of a hydrophobic composition.
公开号:SU1605911A3
申请号:SU864027633
申请日:1986-06-06
公开日:1990-11-07
发明作者:Эдвард Спаркс Роберт；Симон Мазон Норберт；Отан Пьер；Картиллье Андре；Пижон Раймон
申请人:Рон-Пуленк Нютрисьон Анималь (Фирма)；
IPC主号:

专利说明:

FIELD: feed production.
The purpose of the invention is to ensure the stability of the composition at a pH of greater than or equal to 5 (in the rumen) and the release of the biologically active substance at a pH of less than or equal to 3.5 (in the abomasum).
Example 1 (limestone). According to the fluidized bed technology, 200 g of ethionine, previously mixed in the form of spherical particles, of which 98% has a diameter of 0.5-0.6 mm, is coated with a solution containing;
45
Acetobutyrate
pulp
Copolymer 2-vinylpyridine styrene
(70-30) 15 g
Tetrahydrofuran 600 cm
: By coating the film, 260 g of the product is obtained in a shell containing 70% methionine.
The salting out tests were carried out in an aqueous medium with a pH of 2 and 6 with stirring at different time intervals (Table 1).
O5
about SP
with

s
Example 2. Thionine in the form of spherical cores, containing 98% methionine and having a diameter of 0.5-0.63 mm, is pre-coated with a 2-vinylpyridine styrene copolymer (70-30) using a fluidized bed method to obtain pre-coated granules, for which the degree of pre-coating (coating weight / core weight X 100) is A, 25% and the thickness of the pre-coating layer is close to 5 microns.
Example 3. It is carried out similarly to Example 2, but in such a way as to obtain pre-coated methionine, for which the degree of pre-coating is 7% and the thickness of the top-coating layer is close to 8 microns,
Example 4. It is carried out analogously to Example 2, but in such a way as to obtain a pre-coat of methionine, for which the degree of preliminary coating of the shell is 13.5% and the thickness of the preliminary shell is close to 15 microns.
Example 5. 52 g of pre-coated granules prepared in Example 2 are coated by applying a suspension of these granules in 60 g (32.5% by weight of hydr., Fobny composition, rotating at a speed of 2150 rpm) waxed 30 g (50 wt.%), paraffin, whose melting point is 58-63 C (10 g, 16.6 wt.%), US2 NA 601 polyethylene (20 g, 33.3 wt.% ) and 25 cm of a mixture of heptane with octane (1: 1 by volume) at 90 C.
In this way, 12.6 grams of coated methionine granules, which contain 64.7% of methionine, are obtained and the diameter is 0.5-1 mm. For 83% of the obtained granules, the diameter is 0.59-0.86 mm.
Example 6. It is carried out similarly to Example 5, but proceeding from 52 g of pre-coated methio-Nin prepared in Example 3, operating at 9b s, and the rotational speed of the disc is 2160 rpm. The hydrophobic shell is 34.0% by weight of the resulting feed composition.
15.9 g of coated methionine granules containing 61.6 are obtained.
50
50
before
45
Q
five
methionine and a diameter of 0.5-1 mm.
Example 7. It is carried out analogously to Example 5, but starting from 52 g of the pre-coated methionine prepared in Example 4, operating at 98 ° C, the rotational speed of the disk being 2160 rpm. The hydrophobic shell is 33.0% by weight of the resulting feed composition.
12.1 g of coated methionine granules with 60.1% methionine are obtained, the diameter of which is 0.5-1 mm.
Example 8. 52 g of the pre-coated methionine prepared in Example 2 are coated with 100 g of a hydrophobic composition (31.8 wt.%) Formed by a polivok 500 (50 g, 50.0 wt.%), Paraffin (30 g, 30 wt.%), polyethylene 597 (20 g, 20 wt.%), operating with, and the speed of rotation of the disk is 2160 rpm. Thus, 17.6 g of coated methionine granules, containing 65.5% of methionine and having a diameter of 0.5-1 mm, are obtained.
Example 9. It is carried out analogously to Example 8, but starting from 52 g of pre-coated. methionine prepared in Example 3 and 100 g of a hydrophobic composition (34.4 wt.%), operating at a disk rotation speed of 2160 rpm. 17.7 g of coated methionine granules, containing 61.6% of methionine and having a diameter of 0.5-1 mm, are obtained.
Example 10. It is carried out analogously to Example 8, but starting from 52 g of the pre-coated methionine obtained in Example 4 and 100 g of the hydrophobic composition (32.7 wt.%), Operating at 12 ° C, and the rotational speed the disk is 2160 rpm.
17 g of coated methionine granules, containing 59.3% of methionine, the diameter of which is 0.5-1 mm, are obtained.
Example 11. 150 g of pre-coated methionine obtained in Example 2 are coated with 300 g of a hydrophobic (34.3 wt.%) Composition formed by Polyvox 500 (150 g), paraffin
(90 g), polyethylene US2 NA 597 (60 g), operating at 124 ° C, with a disk penetration rate of 2160 rpm.
In this way, 82.6 g grams of coated methionine containing 63% methionine are obtained, the diameter of which is 0.5-1 mm.
Example 12. Operated as in example 11, but based on 155 g before. the varietally-coated methionine prepared in Example 3 and 300 g of the hydrophobic composition. (30.7 wt.%), Operation at 18 ° C, and the speed of rotation of the disk is 2160 rpm.
In this way, 85 g of coated methionine granules with a content of 64.8% methionine are obtained, the diameter of which is 0.5-1 mm.
Example 13. Carried out analogously to example 11, starting from 165 g of pre-coated methionine prepared in example 4 and 300 g of a hydrophobic composition (32.8 wt.%), Operating at, and the speed of rotation of the disk is 2160 rpm .
51.2 g of coated methionine pellets are obtained with a content of 55.3% methionine, the diameter of which is 0.5-1 mm.
Example 14. Spherical methionine granules with a diameter of 0.5-0.63 mm are pre-coated using the fluidized bed method using 7% dimethylaminoethyl methacrylate copolymer and alkyl methacrylate, mol.m. which is “150,000, so that the precoat layer has a thickness close to 8 microns.
The resulting granules are coated with a molten mixture of Polyvox 500 (50), paraffin (30) and US2 NA 597 polyethylene (20). Thus, coated pellets with a content of 56% methionine are obtained, the diameter of which is 0.5-1 mm.
. For the products obtained in examples 2-14, the results are presented in table 2.
In order to emphasize the sensitivity of the products according to the invention by changing the pH, tests are used that allow 20
25
five
U 15
thirty
35 40
45 50
five
Measure the elimination of the active principle as a function of time at various pH values.
The separation of the active substance from the granule form was studied by mixing, under certain conditions, a known amount of granules in a bs-fermented medium maintained at a constant pH at 40 s. Sample rates were compared, subjecting to various pH values,
 namely pH 6 and 2.
The in vivo efficacy of the products according to the invention can be underlined in tests for methioninemia and for determining the concentration of free methionine in the duodenal juice. When conducting the methioninemia test, the appropriate dose of methionine, attributed to the metabolic weight of the animal, is administered daily for 7 days to the sheep. Blood collection is carried out on the sixth and seventh D1SH and blood-related methionine is determined. Compared to identical: conditions, methioninemia caused by protected or unprotected methionine.
The results are presented in table 3. When conducting a test for determining the concentration of free methionine in the duodenal juice, methionine is injected (in the stomach) in appropriate doses, under standard conditions, in sheep with fistulae in the duodenum. On the fourth and fifth days of addition, duodenal juice is taken in which free methionine is analyzed.
The results are presented in table 4.

权利要求:
Claims (1)
[1]
Invention Formula
Food for ruminant animals, including a biologically active substance - methionine, coated with a pH-sensitive membrane, characterized in that, in order to ensure the stability of the composition at a pH of 5 or more (in the rumen) and the release of a biologically active substance at a pH less than or equal to 3.5 (in rennet), as a pH-sensitive shell, the composition contains styrene copolymer with 2-vincipyridine, in a ratio, wt.%, 30.0: 70.0, or dimethylaminostyl methacrylate copolymer with alkyl methacrylate, mol.m. 150000 and additionally a hydrophobic shell consisting of synthetic or natural wax, paraffin and polyethylene, taken in a ratio, wt.%: 50.0: (16.6-30.0) :( 20.0-. 33.3 ), while the pH-sensitive casing is 4.25-13.5% by weight of the resulting feed composition, and hydrophobic - 30.7-34.4 wt.%.
Table 1
T a b l i
c a
Unprotected methiononin
eight
9 10
51 228 362 241

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同族专利:

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公开号 | 公开日

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FR2582909A1|1986-12-12|

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NZ216427A|1990-05-28|

---

EP0206890A2|1986-12-30|

---

FR2582909B1|1991-05-10|

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ES555831A0|1987-03-16|

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DE3673705D1|1990-10-04|

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ES8704073A1|1987-03-16|

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JPS6255047A|1987-03-10|

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AU5838186A|1986-12-11|

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EP0206890A3|1987-07-01|

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CA1278520C|1991-01-02|

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AU595802B2|1990-04-12|

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ZA864203B|1987-02-25|

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EP0206890B1|1990-08-29|

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AT55867T|1990-09-15|

引用文献:

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GB936386A|1959-01-16|1963-09-11|Wellcome Found|Pellets for supplying biologically active substances to ruminants|

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FR7805M|1964-04-09|1970-05-20|

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GB1217365A|1967-02-23|1970-12-31|Labatt Ltd John|Controlled release feed additives for ruminants|

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BE838505A|1976-02-12|1976-05-28|USE OF SULFUR COATED PELLET UREA AS A SOURCE OF NON PROTEIN NITROGEN FOR RUMINANTS|

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FR2401619B1|1977-09-02|1983-02-25|Eastman Kodak Co|

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US4256785A|1979-07-25|1981-03-17|Eastman Kodak Company|Pellet coating process|

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FR2514261B1|1981-10-08|1986-08-22|Aec Chim Organ Biolog|NOVEL COMPOSITION FOR COATING FOODS AND DRUGS AND GRANULES THUS COATED|

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WO1984004657A1|1983-05-26|1984-12-06|Eastman Kodak Co|Rumen-stable pellets|

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US4713245A|1984-06-04|1987-12-15|Mitsui Toatsu Chemicals, Incorporated|Granule containing physiologically-active substance, method for preparing same and use thereof|

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BR8506634A|1984-12-20|1986-09-09|Rhone Poulenc Sante|COMPOSITES FOR COATING FOOD ADDITIVES INTENDED FOR RUMINANTS AND GRANULATES IN THE FORM OF MICROCAPSULES SO COATED|

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AU581691B2|1985-10-14|1989-03-02|Balfour Manufacturing Company Limited|Process for the production of feedstuffs|FR2606597B1|1986-11-17|1989-01-27|Rhone Poulenc Sante|NOVEL COMPOSITION FOR FEEDING RUMINANTS CONTAINING A BIOLOGICALLY ACTIVE SUBSTANCE AND PREPARATION THEREOF|

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JP2547995B2|1987-01-26|1996-10-30|昭和電工株式会社|Granules for ruminants and method for producing the same|

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US4894231A|1987-07-28|1990-01-16|Biomeasure, Inc.|Therapeutic agent delivery system|

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JP2773959B2|1990-07-10|1998-07-09|信越化学工業株式会社|Colon release solid preparation|

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JPH04173060A|1990-11-08|1992-06-19|Ajinomoto Co Inc|Aqua-feed and its production|

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US9259394B2|2009-12-07|2016-02-16|Johnson & Johnson Consumer Inc.|Partial dip coating of dosage forms for modified release|

法律状态:

优先权:

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申请号 | 申请日 | 专利标题

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FR8508626A|FR2582909B1|1985-06-07|1985-06-07|PRODUCT FOR FEEDING RUMINANTS AND ITS PREPARATION.|

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